Validation Protocol (from ICH API) and Impurity Profile

Tsiminal suppresses the (local) Gram-positive and gram- bacteria, promotes epithelialization and wound healing. Slightly soluble in cold water, alcohol, aqueous solutions of the light unstable, becoming brown in color. It has disinfecting and deodorizing effect. Used for washing the purulent wounds (0,2-1%), rinsing the bladder with cystitis (1.2%) purulent conjunctivitis and ophthalmia. With cystitis, urethritis washed with water solutions (0,02%). Used mercury dichloride in solution (1:1000 - 2:1000) for Disinfection of linen, clothes, for washing the walls, care items patients, to disinfect the skin. Indications for its application are cholecystitis, cholangitis, allergic skin diseases, eye (keratitis, Ointment etc.). Action is based on the ability of the drug degraded in the acidic environment with the formation of formaldehyde. Acting on the cerebral cortex, it causes a characteristic alcoholic excitement associated with a weakening of inhibitory processes. Obtained from the distillation of coal tar. When working with him must be very careful. Apply with chronic inflammatory processes skin, boils, carbuncles. When phosphorus burns skin copiously wetted area burned by 5% solution copper sulphate. Zinc ointment, consisting of: zinc oxide, 1 part, 9 parts of petroleum jelly. In clinical practice using both preimuschestvoenno external antiseptic and irritant to cool off, compresses, etc. Salts of heavy metals: Sublimate (mercury dichloride), a heavy white powder, is very active antiseptic and is highly toxic. Zinc oxide, used topically as an astringent and disinfectant skin diseases. azure candles, consisting of: bismuth nitrate, iodine and tannic acid, zinc oxide, resorcinol, methylene blue, oil-based. Antiseptic liquid Novikov, composition: 1 part of tannin, brilliant green 0.2 parts 95% alcohol 0.2 parts castor oil 0.5 parts, 20 parts of collodion. Contain 0.5 g of complex salt of hexamethylenetetramine and calcium chloride. Benzonaftol, antiseptic in diseases of the gastrointestinal tract. Calomel (mercury monochloride) is used externally as Obstetrics and Gynecology for diseases of the cornea, ophthalmia. Silver nitrate (lunar caustic) - in small concentrations has a binder and protivovosplitelnoe action in stronger solutions - cauterizes tissue bactericides. Apply externally for burns, pyoderma, folliculitis, etc. Ethanol is widely used to manufacture of tinctures, extracts and dosage forms for topical use. Used primarily in infectious processes of the urinary tract (Cystitis, pielitah). Apply in cracks and hemorrhoid anus. When long-term use may cause dermatitis, burning azure and itching. For disinfection of premises used carbolic soap-solution. Adults appoint 0,3-0,5 g 3-4 times a day. Assign a powder (for dusting) or 1.3% suspension, which Total Organic Carbon (TOC) to the damaged area, dressing in azure days. Brilliant green, golden-green powder, difficult to dissolve in water and alcohol. Used as azure sterilizing agent for washing hands of surgeons before surgery, cold sterilization equipment (artificial blood flow), surgical instruments. Have antimicrobial action, mainly with infections caused by cocci, particularly streptococci. Dyes: Methylene blue, soluble in water (1:30), it is difficult to alcohol, water solution is blue.