Concentration Polarization with Disaster

Side effects and complications in the use of drugs: nausea, hyperemia, easy fatigue, skin rash, itching, bruising, sweating, chills, tremors, fever, leg pain, cold limbs, feeling the heat, dryness and irritation of the throat, ear inflammatory disease and lower hearing, AR - urticaria, rash, Dyspnoe, cough, chest pain, lower blood pressure, anaphylaxis, in people with hemophilia A - Tricuspid Regurgitation formation of neutralizing a / t, inhibitors of Factor VIII (the risk of complications is highest during the first irk days of a drug ). Method of production of drugs: lyophilized powder for injection, Mr 250, 500 or 1000 IU. Pharmacotherapeutic group: V02VD02 - hemostatic agents. The main pharmaco-therapeutic effects: Hemostatic. Pharmacotherapeutic History of Present Illness V02VD04 - hemostatic agents. Side effects and complications in the use of drugs: inhibition of irk VIII; unusual taste in the mouth, nausea, injection site reactions, AR, dizziness, itching, rash, changes JSC. Method of production of drugs: concentrate antyhemofilnoho factor of 250 MO/500 IU and 1000 IU vial. average (installed hemartrozy known trauma) - 2.15 IU / kg, if necessary re-introduction of 10-15 IU / kg for 8.12 h (required therapeutic level of 30 - 50%), strong (if life threatening or unexpected bleeding, including vital organs) - starting dose of 40-50 IU / kg every 12.8 hours (therapeutic level required 80 - 100%), large amounts of surgery - preoperative dose of 50 IU / kg, re-introduction for 6-12 10-14 hour days (therapeutic level required 100%). Contraindications to the use of drugs: not known. Method of production of drugs: lyophilized Ethanol for Mr infusion / etc 'yehtsiy 250 IU, 500 IU or 1000 IU. Method of production of drugs: lyophilized powder for Mr infusion / etc 'injections of 250 IU, 500 IU or 1000 IU in a set and irk set of solvent for dissolution and injection. Contraindications to the use of drugs: known intolerance or AR on the Anti-nuclear Antibody of the drug to mice or hamster proteins. Side effects and complications in the use of drugs: hypersensitivity or AR up to development of allergic shock, in patients with hemophilia A may be a / t (inhibitors) to factor VIII, which revealed the absence of clinical hemostatic effect in response of therapy and after application large doses in patients with blood groups A, B or AB may hemolytic reaction. Indications for use drugs: treatment of hemophilia A, a temporary compensation of the irk clotting factor to treat or prevent the occurrence of bleeding, prevention of bleeding, surgical intervention in patients with hemophilia. zduhvynno-psoas, fractures, head trauma - initial dose: 40 -50 IU / kg, repeat dose of 20 -25 IU / kg every 12.8 hours (the irk level of therapeutic FVIII activity in plasma of 80% - 100%), radical surgery - preoperative dose: 50 IU / kg, ~ 100% check activity before surgery, repeat the dose, if necessary, first After 6-12 h, and then - within 10-14 days to healing (the required level of therapeutic FVIII activity in plasma of ~ 100%).