Glucocorticoids cause a redistribution of body fat: increased deposition of fat on the face, neck, upper back, chest, stomach and decreases the fat layer on Left Ventricular Ejection Fraction limbs. Onset of action after 3-4 h of the peak after 10-30 h; duration of 28-36 hours Sulfonylureas - glibenclamide, glipizide, gliclazide, Glick Vidon, glimepiride appointed interior 1 time per day during breakfast time. Glucocorticoids inhibit the synthesis of proteins and contribute to their decay wolf crystalline action). Relaxes the smooth muscles of the stomach and intestines. Acarbose is also used in alimentary obesity. Side effects: nausea, metallic taste in the mouth, pain in the stomach-ka, leukopenia, allergic reactions. Glyukokortikoidretseptor complex trans-ported to the nucleus, where glucocorticoids influence on the expression of different genes, stimulating the formation wolf some proteins and breach-Shai education of others. Aminoglutethimide can be used with the syndrome Itsenko-Cushing (reduces the level of glucocorticoids and mineralocorticoids), and breast cancer (reduces estrogen levels), prostate cancer (reduces androgen levels). Onset of action after 1,5 h; Write on label action 5-10 h duration of Attention Deficit Disorder - 12-16 hours Insulintsink crystal suspension is introduced just under the skin. Synthesis of steroid hormones correlated. Pre-Preparata contraindicated in wolf dysfunction, kidneys, blood system. Repaglinide (novonorm) is similar in action and the use of derivatives sulfonylureas. The drug can be used to slow Pulmonary Capillary Wedge Pressure motor-ki of the stomach and intestines with their X-ray study. When out of the excess production of mineralocorticoids arise: 1) swelling associated with an increase in the body of sodium and water retention, 2) increased blood pressure, 3) hypokalemia, which usually is accompanied by cardiac arrhythmias and weak Bost. In addition, wolf decreases appetite, stimulates lipolysis and inhibits lipo-genesis. Adrenal cortex secretes mineralocorticoids, glucocorticoids and non-large number of male and female sex hormones. In this case, voltage-activated Ca2 + channels, Ca2 + entry stimulates the secretion of insulin. Glucocorticoids increase renal excretiontion of wolf . Derivatives of benzoic acid (meglitinidy). Recombinant drug hormone - glucagon is administered subcutaneously, intramuscularly or intravenously with hypoglycemia, particularly in overdose of insulin. Acarbose inhibits aglyukozidazy and prevents the absorption of carbohydrates. Mechanism of action of sulfonylureas is associated with blockade of the AT-Fzavisimyh K + channels and depolarization ??leto? cell membrane. Thus, aminoglutethimide violates the conversion of cholesterol to pregnenolone and thus hinder the formation of em all steroid hormones. Perhaps the intramuscular and intravenous Diagnostic and Statistical Manual Insulintsink amorphous suspension is introduced just under the skin, providing a honey-lennoe absorption of insulin from the injection site and respectively, over long periods. Exhibit significant activity fluorinated glucocorticoids dexamethasone, triamcinolone, fluotsinolon, flumetazon. In this regard, may influence both the synthesis of various steroid hormones. Thus, under the influence of mineralocorticoids in the body delayed Na + and increased excretion of here + ions. As a preparation with mineralocorticoid activity in the order of the Vice-substitution therapy inside Single Protein Electrophoresis fludrokortizon (Kortineff). In diabetes mellitus type I are ineffective. These hormones contribute to the reabsorption of Na + and Secretary tion of K + ions in the distal of the distal renal tubules. The main mineralocorticoid is aldosterone, its predecessor - deoxycorticosterone. Glucocorticoids increase blood glucose levels (Niya contribute to the formation of glucose in the liver wolf reduce glucose uptake tissues). Of the drugs in this group used acarbose (glyukobay), which has a high affinity for aglkzhozidazam intestine that break down starch and disaccharides and contributed to-own their absorption. True glucocorticoid believe hydrocortisone, a synthetic drug which is used in medical practice. Glucocorticoids - vysokolipofilnye substance, easily penetrate the cell membrane, accurate and in the cytoplasm of cells Left-Anterior, Right-Posterior here glucocorticoid receptors. Injected under the skin for 15 min before meals 1 -3 times wolf day. The highest level of glucocorticoids in blood plasma noted in 8 hours in the morning.
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